The saturated fatty acid, palmitic acid, induces anxiety-like behavior in mice

Protective Effects of Linoleic Acid against the Cytotoxicity of Palmitic Fatty Acid in Rat Cardiomyocytes

Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...

Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

Obesity increases the risk for a number of diseases including cardiovascular diseases and type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in cardiovascular diseases by activating innate immunity responses. However, the mechanisms by which SFAs activate the innate immune system are not fully known. Here we report that palmitic acid (PA), the most abundant ...

1. Fatty acids: Palmitic acid, Olic acid, Myristic acid, Stearic acid

High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice

BACKGROUND High-fat diets promote hepatic lipid accumulation. Paradoxically, these diets also induce lipogenic gene expression in rodent liver. Whether high expression of these genes actually results in an increased flux through the de novo lipogenic pathway in vivo has not been demonstrated. METHODOLOGY/PRINCIPAL FINDINGS To interrogate this apparent paradox, we have quantified de novo lipog...

Saturated fatty acid intake and cardiovascular risk.

Since the 1960s, clinical and animal studies have shown that reduction of dietary saturated fatty acid (SFA) consumption is associated with reduced risk of cardiovascular disease (CVD). Thus, reduction of SFA intake is now one of the central strategies of dietary recommendations to reduce CVD worldwide. For example, the World Health Organization and the US Dietary Guidelines recommend dietary c...